Effect of Acitretin Versus Narrowband Ultraviolet B on Neopterin Level in Psoriatic Patients .

South Valley University

Status and phase: Unknown; Phase 4

Conditions: Psoriasis

Treatments: Drug: Acitretin 25Mg Cap; Radiation: Narrowband ultraviolet B

Study type: Interventional

Funder types: Other

Identifiers

NCT05401006

209/6/21

Details and patient eligibility

About

To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.

Enrollment: 30 estimated patients

Sex: All

Ages: 15 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with psoriasis diagnosed clinically Aged (15-60).

Exclusion criteria

• Patient with history of skin cancer.
• Patient with history of photosensitivity.
• Pregnancy and lactation.
• Liver failure.
• Renal failure.
• Patient with psoriatic artheritis.
• Patient with allergy to product or any of its components.
• Patient with poorly controlled dyslipidemia.
• Patient receiving tetracyclines.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Acitretin

Active Comparator group

Description:

Patients will Receive Acitretin (0.25-1 mg /kg/day )for 3months .

Treatment:

Drug: Acitretin 25Mg Cap

Narrowband ultraviolet B

Active Comparator group

Description:

Patients will receive Narrowband UVB( 3session /week ) for 3months.

Treatment:

Radiation: Narrowband ultraviolet B

Combination of Narrowband ultraviolet B and Acitretin

Active Comparator group

Description:

Patients will receive Acitretin (0.25-1 mg /kg/day ) and Narrowband UVB( 3session /week ) for 3 months.

Treatment:

Radiation: Narrowband ultraviolet B

Drug: Acitretin 25Mg Cap