Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest

C

California Baptist University

Status

Completed

Conditions

Obesity

Treatments

Dietary Supplement: Grape seed extract

Study type

Interventional

Funder types

Other

Identifiers

NCT04389060
081-1819-EXP

Details and patient eligibility

About

This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction

Full description

Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.

Enrollment

20 patients

Sex

Male

Ages

18 to 29 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Obesity: body mass index (>30), Normal body weight: body mass index (25-29)

Exclusion criteria

cardiovascular diseases or consume any antihypertensive medication or supplementation that can affect blood pressure or aortic stiffness

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

20 participants in 2 patient groups, including a placebo group

GSE group
Active Comparator group
Description:
Subjects took a single dose of 600 mg GSE in capsule form through ingestion 2 hours prior to testing
Treatment:
Dietary Supplement: Grape seed extract
Placebo group
Placebo Comparator group
Description:
Subjects took a single dose of 600 mg starch in capsule form through ingestion 2 hours prior to testing
Treatment:
Dietary Supplement: Grape seed extract

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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