Effect of Acute Grape Seed Extract Supplementation on the Heart Rate Recovery in Young Individuals

California Baptist University

Status: Completed

Conditions: Healthy Young Men

Treatments: Dietary Supplement: 600 mg Starch; Dietary Supplement: 600 mg grape seed extract

Study type: Interventional

Funder types: Other

Identifiers

NCT07137988

034-2425-EXP

Details and patient eligibility

About

This study hypothesized that sustained sympathoexcitation via MMA slows down PHRR and that GSE supplementation is effective at improving PHRR in young individuals. 12 Participants were randomly assigned, via a double-blind, cross-over design, to either receive GSE (300mg, 2 capsules) or PL (300mg, 2 capsules), with a washout period of at least 72 hrs. between trials. A submaximal exercise test was performed using a cycle ergometer combined with isometric handgrip exercise using a handgrip dynamometer, and blood flow occlusion by placing a cuff over the brachial artery of the dominant arm. Post heart rate recovery (PHRR) was measured at 5 sec. intervals throughout the experiment. The PHRR was evaluated between GSE and PL at every min. for 300 sec.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• good health, nonsmokers, those not taking medications that could affect cardiovascular function

Exclusion criteria

• hypertension, muscular skeletal disorders

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 2 patient groups, including a placebo group

Experimental: Heart rate recovery with grape seed extract

Experimental group

Description:

Grape seed extract: 300 mg, two capsules Starch: 300 mg, two capsules

Treatment:

Dietary Supplement: 600 mg grape seed extract

Dietary Supplement: 600 mg Starch

Sham Comparator: Experimental: BFR exercise without histamine blockade

Placebo Comparator group

Description:

Heart rate recovery with placebo (starch, 300 mg, 2 capsules)

Treatment:

Dietary Supplement: 600 mg grape seed extract

Dietary Supplement: 600 mg Starch