Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs In Laparotomy (ANH)

Universitas Padjadjaran

Status: Completed

Conditions: Surgery

Treatments: Procedure: ANH

Study type: Interventional

Funder types: Other

Identifiers

NCT02290964

AN-201409.01

Details and patient eligibility

About

This study is aimed to determine if acute normovolemic hemodilution (ANH), an established blood conservation technique, reduces the requirement for allogeneic blood transfusion in operations with prediction of surgical bleeding over 20% of estimated blood volume (EBV)

Full description

Allogeneic blood transfusion is often done during surgery to save life- threatening conditions. Blood conservation is a method that can reduce peri-operative allogeneic blood transfusion. This study has been conducted on 34 patients underwent laparotomy surgery with bleeding more than 20% of EBV. After being informed concent, research subjects were randomized into two groups: ANH (conducted ANH) and control group (without ANH). After starting general anesthesia, the ANH group was withdrawing blood based on Gross formula. Restoration of circulated volume was instituted by infusion of colloids. In control group, the operation was started right after the induction of anesthesia. The monitoring of blood pressure, heart rate, the amount of bleeding, total fluid, urine production, hemoglobin concentration and number of allogenic transfusion were recorded.

Enrollment: 34 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients scheduled for laparotomy under general anesthesia with potentially surgical bleeding > 20% of EBV
• ASA physical status I - II
• hemoglobin level before surgery > 11 g / dl for men and > 10 g / dl for women

Exclusion criteria

• impaired coagulation (INR> 1.5 and / or platelet count <100,000)
• active infection
• disruption of metabolic liver
• received anti fibrinolytic drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

34 participants in 2 patient groups

Control group

No Intervention group

Description:

After general anesthesia is applied, surgery is performed. Whenever transfusion is indicated, the patients will received allogenic blood transfusion

ANH group

Active Comparator group

Description:

After general anesthesia is applied, blood from patients in this group were withdrawn. the volume of blood withdrawn was determined based on Gross equation. The blood obtained was then stored in the operating room at temperature between 23 - 25 Celsius degree, and given back to the patient whenever transfusion is indicated.

Treatment:

Procedure: ANH