Effect of Acute Red Raspberry Consumption on Post-prandial Oxidative Stress

University of Toronto

Status: Completed

Conditions: Antioxidants; Oxidative Stress

Treatments: Dietary Supplement: bread controls; Dietary Supplement: red raspberries

Study type: Interventional

Funder types: Other

Identifiers

NCT01242033

24774

Details and patient eligibility

About

Eight healthy adult subjects will be given a meal of one, two or four cups red raspberries, or two slices white bread with or without 200 mg vitamin C, after an overnight fast and consumption of a low polyphenol diet for two days. Blood samples will be taken at various time points over an eight hour period to measure oxidative stress and antioxidant levels in the blood. Each subject will attend 5 study visits with one week intervals and be given each meal in a random order. It is hypothesized that raspberry consumption at higher doses will greater protect against meal-induced oxidative stress compared to bread controls.

Enrollment: 8 patients

Sex: All

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults

Exclusion criteria

• blood pressure greater than 120/80 mm Hg
• body mass index greater than 24.9 kg/m^2
• history of any chronic disease
• currently taking medications
• allergy to fruit

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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8 participants in 5 patient groups, including a placebo group

one cup red raspberries

Experimental group

Description:

treatment meal consists of one cup red raspberries

Treatment:

Dietary Supplement: red raspberries

two cups red raspberries

Experimental group

Description:

treatment meal consists of two cups red raspberries

Treatment:

Dietary Supplement: red raspberries

four cups red raspberries

Experimental group

Description:

treatment meal consists of four cups red raspberries

Treatment:

Dietary Supplement: red raspberries

bread

Placebo Comparator group

Description:

treatment meal consists of two slices white bread

Treatment:

Dietary Supplement: bread controls

vitamin C

Active Comparator group

Description:

treatment meal consists of two slices white bread and 200 mg vitamin C in the form of supplemental ascorbic acid

Treatment:

Dietary Supplement: bread controls