Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Pain

Treatments: Drug: Air; Drug: N2O

Study type: Interventional

Funder types: Other

Identifiers

NCT01616004

TASMC-12-SB-340-CTIL

Details and patient eligibility

About

The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.

Full description

10 healthy volunteers will come twice to the pain medicine unit, at 1 visit they'll get N2O and in the second visit they'll get air as placebo, they won't know what they're getting. During the visit they'll get heat stimulus using QST and will have to report their pain using eVAS (scale from 0 to 100 when 0 is no pain and 100 is the worst pain imagine).

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-50 years old
• women and men
• healthy

Exclusion criteria

• smokers
• medication use pregnant woman cardiovascular disease

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

10 participants in 2 patient groups

N2O

Experimental group

Description:

N20 70% inhalation 5 minutes O2 100 % inhalation for 5 minutes

Treatment:

Drug: N2O

Air

Sham Comparator group

Treatment:

Drug: Air