Effect of Adding Blood Flow Restriction to Strengthening Exercise in Patients With Patellofemoral Pain Syndrome (BFR)

Cairo University (CU)

Status: Not yet enrolling

Conditions: Joint Position Sense; PFPS; Dynamic Balance; BFR; Quadriceps Strength; Strengthening Exercises

Treatments: Other: strengthening exercise; Other: BFR

Study type: Interventional

Funder types: Other

Identifiers

NCT06565754

P.T.REC/012/005148 (Other Identifier)

Details and patient eligibility

About

To study the effect of adding BFRT to strengthening exercises and compare it with strengthening exercises alone in improving, muscular strength, pain, function, joint position sense, and dynamic balance test (star excursion test). in patients with PFPS.

Full description

Background: Patellofemoral Pain Syndrome (PFPS) is a common condition characterized by anterior knee pain, particularly affecting individuals aged 15-30. It often involves lower limb muscle weakness, particularly in the quadriceps, which can exacerbate symptoms and affect functional performance. Blood Flow Restriction Training (BFRT) has shown promise in enhancing muscle strength and functional outcomes with reduced intensity compared to traditional high-intensity training.

Purpose: This study aims to compare the efficacy of combining BFRT with traditional strengthening exercises versus using strengthening exercises alone in improving muscular strength, pain, function, joint position sense, and dynamic balance in patients with PFPS.

Methods: A triple-blinded, randomized controlled trial was conducted at the Almenshawy General Hospital, Tanta, Egypt. Fifty patients with unilateral non-traumatic PFPS, aged 18-35, were randomly assigned to either a strengthening exercises group (SE Group) or a BFRT plus strengthening exercises group (BFRT Group). Both groups underwent a 6-week intervention with three sessions per week. Outcomes assessed included quadriceps and hip abductors strength, pain severity (Visual Analog Scale), functional status (Kujala Patellofemoral Score), joint position sense (measured by digital inclinometer), and dynamic balance (Star Excursion Balance Test).

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient referred from Orthopedic surgeon with diagnosis of patellofemoral pain syndrome PFPS.
• Both genders.
• BMI ranges from 18.5 to 29.9.
• Age ranges between 18 and 40 years experienced non-traumatic PFPS onset of anterior knee pain for greater than 2 weeks.
• Pain with any two activities, including running, jumping, squatting, kneeling, stair ascent/descent or prolonged sitting.

Exclusion criteria

• Coexisting pathology around the knee, including patellar subluxation or dislocation.
• Other sources of anterior knee pain (bursa, fat pad).
• Previous knee surgery.
• Suspicion of patellar tendinopathy, with strong consideration of pain localised to the patellar tendon.
• Any cardiovascular disease.
• Uncontrolled hypertension.
• Any lower limb trauma.
• Hip and ankle pathology.
• BMI more than 30%.
• Pregnancy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups

strengthening exercises group (SE Group)

Active Comparator group

Description:

all patients will receive : 1. Isometric quadriceps exercise - 3 sets of 20 repetitions (5 s). 2. Straight leg raise (SLR) with 3 sets - 20 repetitions. 3. Short arc knee extension exercise - 3 sets of 20 repetitions. 4. Hip abduction from side lying - 3 sets of 20 repetitions.

Treatment:

Other: strengthening exercise

BFRT plus strengthening exercises group (BFRT Group)

Experimental group

Description:

all patients will receive the below exercises using BFR cuff : 1. Isometric quadriceps exercise - 3 sets of 20 repetitions (5 s). 2. Straight leg raise (SLR) with 3 sets - 20 repetitions. 3. Short arc knee extension exercise - 3 sets of 20 repetitions. 4. Hip abduction from side lying - 3 sets of 20 repetitions.

Treatment:

Other: BFR

Other: strengthening exercise