Effect of Adding Magnesium Sulphate in Pericapsular Nerve Group Block (Peng Block)

Assiut University

Status and phase: Not yet enrolling; Phase 3; Phase 2

Conditions: Hip Fractures

Treatments: Drug: Pericapsular nerve group block using bupivicaine and magnesium sulphate

Study type: Interventional

Funder types: Other

Identifiers

NCT06180031

04-2023-200535

Details and patient eligibility

About

Our aim will be to compare the analgesic efficacy and safety of magnesium sulphate as an adjuvant to bupivacaine in pericapsular nerve group block in Hip joint surgeries.

• Our primary outcome of the study: total amount of postoperative morphine consumption in the first 24h postoperative.
• Our secondary outcome of the study: mean arterial blood pressure, heart rate, respiratory rate, adverse effects, block related complication, sedation score (by Ramsay sedation scale) and pain score (by Visual Analog Scale)

Enrollment: 62 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Patients aged 18 years or more.

  • Patients with American society of anesthesiologists (ASA) classification class I or II
  • Patients weight range from 50 to 90 Kgs

Exclusion criteria

• • Patient refusal of peripheral nerve block

  • Patient with infection at the site of injection
  • Patient with coagulopathy
  • Patients with known allergy to used medications.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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62 participants in 2 patient groups

Group C (control)

No Intervention group

Description:

will have Peng block using 20mg bupivacaine 0.25%

Group M

Active Comparator group

Description:

will have PENG block with 2mg magnesium sulphate 10% as an adjuvant to 20mg of bupivacaine 0.25%

Treatment:

Drug: Pericapsular nerve group block using bupivicaine and magnesium sulphate