Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles (sildenafil)

farzaneh hojjat

Status and phase: Completed; Phase 4

Conditions: Frozen Embryo Transfer; Endometrial Preparation

Treatments: Drug: estradiol valerat; Drug: Sildenafil

Study type: Interventional

Funder types: Other

Identifiers

NCT01668446

rad123 (Other Identifier)

radvin123

Details and patient eligibility

About

The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .

Enrollment: 2 patients

Sex: Female

Ages: 20 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women > 40 years old,
• history of endocrine disease
• Hysteroscopic surgery
• cardiovascular, renal and liver disease
• hypotension( blood pressure < 90/50)
• history of stroke or myocardial infarction
• use of alcohol or substance

Exclusion criteria

A total of 80 patients with antecedent of poor endometrial response and had frozen embryo included in this study all women must to be < 40 years old,

• no history of endocrine disease,
• no Hysteroscopic surgery, had a high quality embryos no cardiovascular,
• renal and liver disease and
• no hypotension (blood pressure < 90/50) or
• history of stroke or myocardial infarction and
• don't use of alcohol or substance Patients with these conditions enter this study and based on randomized tables are divided in two groups.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

---

2 participants in 2 patient groups

sildenafil

Experimental group

Description:

One of two group to prepare the endometrium give estradiol by step up method with menstruation. From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily.

Treatment:

Drug: Sildenafil

Sildenafil and estradiol valerat

Experimental group

Description:

One of two group to prepare the endometrium give estradiol by step up method with menstruation. From first to fourth day of menstrual cycle, estradiol valerat tablet 2 mg daily From Fifth to eighth day of menstrual cycle, estradiol valerat tablet 4 mg daily From Ninth to twelfth day of menstrual , estradiol valerat tablet 6 mg daily The second group in addition to the above treatment protocol from First day of cycle until day of starting progesterone will be given sildenafil tablets(50 mg) daily.

Treatment:

Drug: estradiol valerat

Drug: Sildenafil