Effect of Addition of Fentanyl or Dexamethasone or Both to Bupivacaine in Paravertebral Block for Patients Undergoing Major Breast Surgery

Assiut University

Status: Unknown

Conditions: Paravertebral Block

Treatments: Drug: Dexamethasone; Drug: Fentanyl; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT03480308

paravertebral block

Details and patient eligibility

About

This study evaluated the analgesic efficacy of fentanyl and dexamethasone in combination with bupivacaine for single-shot paravertebral block (PVB) in patients undergoing major breast surgery.

Full description

This study evaluated the analgesic efficacy of fentanyl and dexamethasone in combination with bupivacaine for single-shot paravertebral block (PVB) in patients undergoing major breast surgery.

Patients will receive ultrasound guided paravertebral block and stratified into 3 groups according to medication used :

Group 1 : bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg Group 2 : bupivacaine (0.5%) 20 ml , dexamethasone 4 mg Group 2 : bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg , dexamethasone 4 mg

Enrollment: 1 estimated patient

Sex: Female

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 18-70 years.
• Sex: females
• ASA physical status: I-II.
• Operation: major breast surgery

Exclusion criteria

• • Patient refusal.
• History of cardiac disease, psychological disorders, respiratory diseases including asthma, renal or hepatic failure.
• Coagulation disorders.
• Infection at the puncture site
• Allergy to study medications.
• Chronic use of pain medications.
• Respiratory tract in¬fection within the last 2 weeks.
• Neurological deficit

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1 participants in 3 patient groups

Bupivacaine fentanyl group

Active Comparator group

Description:

Patients will receive bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg in paravertebral block

Treatment:

Drug: Bupivacaine

Drug: Fentanyl

Bupivacaine dexamethasone group

Active Comparator group

Description:

Patients will receive bupivacaine (0.5%) 20 ml , dexamethasone 4 mg in paravertebral block

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine

Bupivacaine fentanyl dexamethasone group

Active Comparator group

Description:

Patients will receive bupivacaine (0.5%) 20 ml , fentanyl 1 μg/kg , dexamethasone 4 mg in paravertebral block

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine

Drug: Fentanyl