Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain

Cairo University (CU)

Status and phase: Completed; Phase 3; Phase 2

Conditions: Irreversible Pulpitis

Treatments: Drug: bupivacaine plus mannitol; Drug: bupivacaine alone

Study type: Interventional

Funder types: Other

Identifiers

NCT03749408

CEBD-CU-2012-12-24

Details and patient eligibility

About

Inferior alveolar nerve block using either 0.5% bupivacaine alone or in addittion to mannitol in patients with irreversible pulpitis in mandibular molars.

Full description

Patients with irreversible pulpitis in mandibular molars will be selected according to the eligibility criteria and patients are then randomized to either using 0.5% bupivacaine alone or in addition to mannitol. Anesthetic success and postoperative pain will then be assessed.

Enrollment: 60 patients

Sex: All

Ages: 17 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adult patients; age between 17-35 years old.
2. Males or Females.
3. Medically-free patients
4. Patients suffering from symptomatic irreversible pulpitis without apical periodontitis in mandibular molar teeth.
5. Positive patients' acceptance for participation in the study.

Exclusion criteria

• Patients who had any analgesic during proceeding 12 hours before the treatment.
• Teeth with necrotic, infected pulp, swelling or symptomatic apical periodontitis (apical abscess).
• Pregnant females.
• Patients with history of significant medical conditions (contraindication of mannitol use).
• Addiction
• Psycological disturbance.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 2 patient groups

bupivacaine plus mannitol

Active Comparator group

Description:

0.5% bupivacaine with 1:200,000 epinephrine plus 1.5 ml of 0.5 mol/L mannitol

Treatment:

Drug: bupivacaine plus mannitol

bupivacaine alone

Experimental group

Description:

0.5% bupivacaine with 1:200,000epinephrine alone

Treatment:

Drug: bupivacaine alone