Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction

Istanbul University

Status and phase: Completed; Phase 4

Conditions: Acute Coronary Syndromes; Acute Myocardial Infarction; Reperfusion Injury

Treatments: Procedure: primary percutaneous coronary intervention; Drug: Streptokinase

Study type: Interventional

Funder types: Other

Identifiers

NCT00627809

2007-337

Details and patient eligibility

About

The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in left ventricular volumes and function in acute and late phases (6 months).

Enrollment: 53 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Continuous chest pain that lasted > 30 minutes within the preceding 12 hours
• ST-segment elevation of at least 1 mm in 2 contiguous leads on the ECG
• Infarct related artery (IRA) occlusion (TIMI grade 0) at the angiography

Exclusion criteria

• Contraindications to streptokinase, tirofiban, aspirin, clopidogrel, or heparin
• Culprit lesion in saphenous vein graft
• TIMI grade II-III flow in IRA
• Additional epicardial stenosis in the IRA distal to stented segment (significant or insignificant)
• Presence of left bundle branch block
• History of prior MI

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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53 participants in 2 patient groups

1

Experimental group

Description:

Following standard primary percutaneous coronary intervention for ST elevation acute myocardial infarction 250.000 U intracoronary Streptokinase will be given

Treatment:

Procedure: primary percutaneous coronary intervention

Drug: Streptokinase

2

Active Comparator group

Description:

Standard percutaneous coronary intervention for ST elevation myocardial infarction will be performed

Treatment:

Procedure: primary percutaneous coronary intervention