Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis

OraPharma

Status and phase

Completed

Phase 3

Conditions

Periodontitis

Treatments

Drug: Minocycline HCL Microspheres

Study type

Interventional

Funder types

Industry

Identifiers

OPI-145'

Details and patient eligibility

About

The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease

Sex

All

Ages

30 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Generalized moderate to advanced chronic periodontitis, five sites with probing depths of >5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants

Exclusion criteria

Allergy to tetracycline
Subjects with aggressive periodontitis
Acute necrotizing ulcerative gingivitis, or gross decay
Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc)
Individuals requiring prophylactic antibiotics
Any periodontal therapy within the previous 3 months (excluding maintenance therapy)
Systemic or local antibiotic therapy within three months