Effect of Aerobic Exercise on Biomarkers in Depression

Kutahya Health Sciences University

Status: Enrolling

Conditions: Major Depression

Treatments: Other: Aerobic Exercise; Other: Breathing exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT07062783

DAE1

Details and patient eligibility

About

This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals who volunteer to participate in the study,
• Between the ages of 18 and 40,
• Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria

Exclusion criteria

• Individuals with chronic conditions accompanying depression,
• Those with walking difficulties
• Those with respiratory system disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

40 participants in 2 patient groups

Exercise Group

Experimental group

Description:

Those included in the experimental group continued diaphragmatic breathing exercises every day for three weeks and walking exercises at least three days a week.

Treatment:

Other: Breathing exercise

Other: Aerobic Exercise

Control group

No Intervention group

Description:

The control group continued their routine lives, and at the end of three weeks