Effect of Aerobic Exercise on Side Effects of Disease Modifying Therapy With Subcutaneous Interferon-b1b in Patients With Multiple Sclerosis

University of British Columbia

Status: Completed

Conditions: Multiple Sclerosis

Treatments: Other: Physical exercise training

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01122056

H10-00277

Details and patient eligibility

About

The purpose of this study is to investigate the effects and tolerability of exercise on side effects of injectable disease modifying treatments in multiple sclerosis. The investigators main hypothesis is that controlled exercise is safe and can be well tolerated in patients with multiple sclerosis and it can improve disease modifying treatment related side effects such as fatigue.

Full description

Patient compliance with disease modifying treatment largely depends on relatively common side effects of such treatments such as fatigue. Regular exercise can potentially improve these side effects. However, Safety and effects of exercise has not been studied in patients with multiple sclerosis. Our main aim is to study the safety, tolerability and effects of exercise on side effects of subcutaneous interferon-b1b in patients with Multiple Sclerosis.

Enrollment: 128 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Recent diagnosis of relapsing remitting multiple sclerosis on treatment with b1b-interferon disease modifying treatment

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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128 participants in 2 patient groups

A = Active group

Active Comparator group

Description:

Patients will receive interactive exercise training session from an experienced multiple sclerosis

Treatment:

Other: Physical exercise training

B = Control group (Placebo Comparator)

No Intervention group

Description:

Patients will receive general advice about benefits/side effects of physical activity in multiple sclerosis.