Effect of Aerobic Interval Training on Cardiovascular Function in Aging

University of Florida

Status: Completed

Conditions: Aging

Treatments: Other: Continuous moderate intensity exercise; Other: High intensity aerobic interval training

Study type: Interventional

Funder types: Other

Identifiers

NCT01883271

IRB201700044

551-2012 (Other Identifier)

Details and patient eligibility

About

Study objectives:

1. To compare cardiovascular function in older compared to young healthy adults.
2. To compare the effect of 8 weeks of aerobic interval training vs. continuous moderate exercise on cardiovascular function in healthy older adults.

Hypotheses:

1. Compared to young adults, older adults will have lower cardiovascular function.
2. Compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in older adults.

Full description

Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week exercise intervention, baseline measures will be repeated in the older adults.

Enrollment: 60 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for older adults:

• Healthy men and women 55 to 79 years of age
• Sedentary or minimally physically active for at least the prior 1 year.
• Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
• Premenopausal women will be eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
• Able to give consent.

Inclusion Criteria for young adults:

• Healthy men and women 18 to 35 years of age
• Sedentary or minimally physically active for at least the prior 1 year.
• Women will be premenopausal, eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
• Able to give consent.

Exclusion Criteria:

• history of diabetes

• history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)

• hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)

• history of renal impairment

• history of gout or hyperuricemia

• history of hepatic disease or infection with hepatitis B, C

• history of seizures, or other relevant on-going or recurrent illness

• recent (within 3 months) or recurrent hospitalizations

• use of tobacco products

• >5 % weight change in the prior 6 months.

• current intake of medications that may affect study results

• participation in regular aerobic exercise training (>30 minutes,

  • 3 times/wk in the past year).

• premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.

• pregnancy (positive urine pregnancy test) or lactation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 4 patient groups

High intensity aerobic interval training

Experimental group

Description:

Older adults will complete 8 weeks of high intensity aerobic interval exercise training.

Treatment:

Other: High intensity aerobic interval training

Continuous moderate intensity exercise

Experimental group

Description:

Older adults will complete 8 weeks of continuous moderate intensity exercise training.

Treatment:

Other: Continuous moderate intensity exercise

Non-exercise control group

No Intervention group

Description:

Older adults assigned to the non-exercise control group will maintain their normal lifestyle for 8 weeks.

Young Healthy controls

No Intervention group

Description:

Young healthy subjects will be assigned to the healthy control group and will undergo baseline measures only.