Effect of Aerobic Training on Asthmatic Patients

University of Sao Paulo General Hospital

Status: Completed

Conditions: Airway Inflammation; Depression; Anxiety

Treatments: Other: Aerobic training

Study type: Interventional

Funder types: Other

Identifiers

NCT00989365

Asthmatraining

Details and patient eligibility

About

The investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.

Full description

One-hundred patients with moderate or severe persistent asthma, age ranging from 20 to 50 years-old recruited after a medical consultation. Asthma diagnosis based on GINA1 and patients were under medical treatment for at least 6-months and considered clinically stable (no crises and changes in medication for at least 30 days). Patients diagnosed with cardiovascular, pulmonary or musculoskeletal diseases impairing exercise training were excluded.

Experimental Design: Patients were studied between 2 medical consultation to avoid changes in medication during the study and patients were randomized (by drawing lots) into either Control or Training groups. CG was submitted to a 4-hour educational program and a breathing exercise program and TG was submitted to the same CG procedures plus an aerobic training program individually based on VO2max. Before and after the intervention, patients performed pulmonary function test and cardiopulmonary exercise testing and as well as fulfilled questionnaires to quantify asthma specific HRQL and anxiety and depression levels. Asthma daily symptoms were evaluated monthly.

Enrollment: 100 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20-50 years old
• moderate and severe asthma

Exclusion criteria

• other pulmonary or cardiovascular disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Patient cousenling

Other group

Description:

Improve medicine use Self control asthma crisis Ambient hygiene

Treatment:

Other: Aerobic training