Effect of Aerobic Training on Oxidative Stress Markers in Patients With Parkinson's Disease

Saglik Bilimleri Universitesi

Status: Not yet enrolling

Conditions: Parkinson Disease

Treatments: Other: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT05511402

630

Details and patient eligibility

About

Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors. One of the most important factor that is responsible for the initation and progression of the disease is oxidative stress. Exercise training, especially aerobic training, can change the levels of oxidative markers because exercise can lead to decrease oxidative stress in patients with Parkinson's disease. Therefore, this study aims to investigate (1) the effect of aerobic training on total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels, (2) the relationship between the change of motor symptoms and disease severity and the change of total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels.

Enrollment: 28 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• at least 40years of age
• diagnosed with Parkinson's Disease
• Hoehn and Yahr stage of 1 and 3

Exclusion criteria

• any other neurologic disorders,
• any cardiovascular, orthopedic, vestibular or rheumatic conditions that impact exercise training
• visual, auditory, and perception problems.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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28 participants in 2 patient groups

Aerobic exercise

Experimental group

Description:

This group will participate in an aerobic training program (8-week, 3 times weekly, and 30-min each time) and conventional physiotherapy program (8-week, 3 times weekly, and 45-min each time).

Treatment:

Other: Exercise training

Conventional physiotherapy

Active Comparator group

Description:

This group will participate in a conventional physiotherapy program (8-week, 3 times weekly, and 45-min each time).

Treatment:

Other: Exercise training