Effect of Ageing on Airway Remodeling

University Hospital Center (CHU)

Status: Terminated

Conditions: Aging

Treatments: Other: EFR and TDM

Study type: Interventional

Funder types: Other

Identifiers

NCT01230879

8268

Details and patient eligibility

About

The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.

Full description

Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome

Enrollment: 101 patients

Sex: All

Ages: 60 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• People from 60 to 95 years old free from chest disease or history of chest disease

Exclusion criteria

• Chronic cough
• Dyspnea
• Sinonasal or chest infection during enrollment
• Myocardial infarction.
• Current smoker or past smoker with more than 10 pack year intoxication

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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101 participants in 3 patient groups

60 - 70 years old

Experimental group

Description:

EFR and TDM

Treatment:

Other: EFR and TDM

71 - 80 years old

Experimental group

Description:

EFR and TDM

Treatment:

Other: EFR and TDM

81 - 95 years old

Experimental group

Description:

EFR and TDM

Treatment:

Other: EFR and TDM