Effect of Aging & Obesity With Exercise Intervention

Seoul National University

Status: Completed

Conditions: Obesity

Treatments: Other: Resistance exercise with a gym stick

Study type: Interventional

Funder types: Other

Identifiers

NCT03951857

B-1610-365-001

Details and patient eligibility

About

Obesity leads to a vicious circle that increases intramuscular fat, insulin resistance, promotes muscular dysfunction resulting in increased muscle fat accumulation. The study of muscle function and intramyocellular lipids is insufficient for obesity. Particularly, the study of mechanisms in muscle function and intramyocellular lipids is few nationally and internationally.

Full description

This study is prospective study. The goal of this study is

1. To examine the distribution and contractile properties (cross-sectional area, maximal force, specific force, maximal shortening velocity) of single muscle fiber sex/Myosin heavy chain (MHC) type-related differences, by extracting a single muscle fiber from the vastus lateralis in young men and women.
2. To examine the effects of intramyocellular lipids on physical activity ability, muscle dysfunction, and metabolic disorders in relation to aging and obesity.
3. To examine the effects of intramyocellular lipids on physical activity ability, muscular dysfunction, and metabolic disorders after 12 weeks resistance exercise intervention.

Enrollment: 28 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Young men: Age (20-35 yrs), BMI (19-23 Kg/m2)
• Young women: Age (20-35 yrs), BMI (19-23 Kg/m2)
• Elderly women: Age (65-80 yrs), BMI (19-23 Kg/m2)
• Elderly obese women: Age (65-80 yrs), BMI ( >25 Kg/m2)
• Subjects who can agree voluntarily.

Exclusion criteria

• Acute coronary syndrome.
• Uncontrolled hypertension.
• Subjects who took drugs which can affects neuromuscular system.
• Severely impaired cognition
• Subjects who cannot agree voluntarily

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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28 participants in 4 patient groups

Young men

No Intervention group

Description:

Range of age is 20-35 years, young men (BMI 19-23 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Young women

No Intervention group

Description:

Range of age is 20-35 years, young women (BMI 19-23 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Elderly women (control)

Experimental group

Description:

Range of age is 65-80 years, Elderly women (BMI 19-23 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Treatment:

Other: Resistance exercise with a gym stick

Elderly obese women

Experimental group

Description:

Range of age is 65-80 years,Elderly obese women (BMI ≥25 Kg/m2) They did not suffer from musculoskeletal or metabolic diseases, and had not performed regular exercise within the previous 3 months.

Treatment:

Other: Resistance exercise with a gym stick