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Effect of Allopurinol Treatment on Insulin Resistance

I

Istanbul Medeniyet University

Status

Unknown

Conditions

Prediabetes
Hyperuricemia
Insulin Resistance

Treatments

Drug: allopurinol 300 mg./day
Drug: Normouricemic
Other: No intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT02008968
Allo2013

Details and patient eligibility

About

Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin resistance of which is also named as prediabetes. With this background in mind, we aimed to test the effect of lowering serum uric acid level with allopurinol on insulin resistance.

Enrollment

130 estimated patients

Sex

All

Ages

30 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age ≥ 30
  • Serum uric acid level ≥7mg/dL
  • Glomerular filtration rate ≥60 ml/min

Exclusion criteria

  • presence of Diabetes Mellitus
  • history of gout
  • history of allopurinol use
  • body mass index ≥35 kg/m2
  • proteinuria ≥ 1gr/ day
  • presence of autoimmune disease
  • rheumatology associated disease
  • presence of hypothyroidism or hyperthyroidism
  • presence of diseases which may cause chronic inflammation or microalbuminuria (e.g. malignancy, chronic liver disease, hypertension, chronic lung disease)

Trial design

Primary purpose

Prevention

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

130 participants in 3 patient groups, including a placebo group

Uric acid ≥7 mg/dL
Active Comparator group
Description:
This arm will receive allopurinol treatment. 50 subjects will be recruited.
Treatment:
Drug: allopurinol 300 mg./day
Uric acid ≥6 and <7
Active Comparator group
Description:
This arm will not receive allopurinol. 50 subjects will be recruited.
Treatment:
Other: No intervention
Normouricemic
Placebo Comparator group
Description:
This arm is healthy controls. 30 subjects will be recruited.
Treatment:
Drug: Normouricemic

Trial contacts and locations

1

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Central trial contact

Mehmet Kanbay, Associate Professor

Data sourced from clinicaltrials.gov

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