Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids1

Loughborough University

Status: Completed

Conditions: Rate of Water Appearance/Delivery in the Blood Water Balance

Treatments: Other: Composition of Sports Drink

Study type: Interventional

Funder types: Other

Identifiers

NCT04819334

LEON3151

Details and patient eligibility

About

To determine the effects of a moderate amount of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials. In each trial, volunteers will be given one of two commercially available sports drinks or a commercially available sport drink with added amino acids in a double-blinded, randomised, crossover design. Each drink will be a single 600 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be compared for temporal accumulation of deuterium in plasma over the course of 60 minutes. Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume changes calculated. It is hypothesised that the amino acid trial will increase the rate of fluid absorption.

Enrollment: 15 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Generally fit and healthy (determined by health screen questionnaire)
• Recreationally active (minimum 3 hours of physical activity per week including walking)

Exclusion criteria

• Any cardiovascular, gastrointestinal, renal or acute/chronic health conditions that may influence the outcomes
• Smoking (including vaping)
• BMI of greater than 30 (combined with a body fat percentage greater than 20%) or BMI lower than 17.5

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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15 participants in 3 patient groups, including a placebo group

Commercially Available Sports Drink A

Placebo Comparator group

Description:

A commercially available flavored electrolyte solution, The Coca-Cola Company

Treatment:

Other: Composition of Sports Drink

Commercially Available Sports Drink B

Experimental group

Description:

A commercially available flavored electrolyte solution, PepsiCo

Treatment:

Other: Composition of Sports Drink

Commercially Available Sports Drink A with added Amino Acids

Experimental group

Description:

he same as sports drink A above (a commercially available flavored electrolyte solution, The Coca-Cola Company), but with the addition of a small amount of amino acids (\~2.6 g/100 ml).

Treatment:

Other: Composition of Sports Drink