Effect of Amino Acid on Muscle Damage

University of Toronto

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Active; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03319147

EAA

Details and patient eligibility

About

The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.

In addition, the secondary objective is to determine the effect of essential amino acids on satellite cell regulation and inflammatory responses during this prolonged recovery period.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy, male, recreationally-active participants
• Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone; Appendix. B). Active will be defined as being in the top 20% of age specific scores on iPAQ (the International Physical Activity Questionnaire; Appendix.C).
• Participants are required not to engage in lower limb RT (resistance training) for at least 6 months prior to the study.
• Participants will be 18-35 years old.
• Participants are willing to abide by the compliance rules of this study

Exclusion criteria

• Female
• Inability to adhere to any of the compliance rules judged by principle investigator or medical doctor
• Self-reported regular tobacco use
• Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
• The individual who has allergy for milk

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

4g of maltodextrin

Treatment:

Dietary Supplement: Placebo

Active

Active Comparator group

Description:

4g of essential amino acids

Treatment:

Dietary Supplement: Active