Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans

University Hospital Basel

Status: Completed

Conditions: Endocrine System Diseases

Treatments: Dietary Supplement: 75 g Erythritol; Dietary Supplement: 1.56 g L-Tryptophan; Dietary Supplement: 1.56 g L-Leucine; Dietary Supplement: 300 mL tap water; Other: 50 mg 13C-sodium acetate; Dietary Supplement: 75 g Glucose; Dietary Supplement: 50 g Xylitol; Dietary Supplement: 0.52 g L-Tryptophan

Study type: Interventional

Funder types: Other

Identifiers

NCT02563847

EKBB 2014/072

Details and patient eligibility

About

With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.

Enrollment: 20 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy normal weight subjects with a body-mass index of 19.0-24.9
• Healthy obese subjects with a body-mass index of > 30
• Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
• Age 18-40 years
• Stable body weight for at least three months

Exclusion criteria

• Smoking
• Substance abuse
• Regular intake of medications (except for oral contraceptives)
• Medical or psychiatric illness
• History of gastrointestinal disorders
• Food allergies
• Pregnancy, breast feeding

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 7 patient groups, including a placebo group

0.52 g L-Tryptophan

Active Comparator group

Description:

0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 0.52 g L-Tryptophan

1.56 g L-Tryptophan

Active Comparator group

Description:

1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 1.56 g L-Tryptophan

1.56 g L-Leucine

Active Comparator group

Description:

1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 1.56 g L-Leucine

50 g Xylitol

Active Comparator group

Description:

50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 50 g Xylitol

75 g Erythritol

Active Comparator group

Description:

75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 75 g Erythritol

75 g Glucose

Placebo Comparator group

Description:

75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 75 g Glucose

Tap water

Placebo Comparator group

Description:

300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube

Treatment:

Other: 50 mg 13C-sodium acetate

Dietary Supplement: 300 mL tap water