Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions

University Hospital Basel

Status: Completed

Conditions: Endocrine System Diseases

Treatments: Device: Nasogastric Tube; Dietary Supplement: 1.56 g L-Tryptophan; Dietary Supplement: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate); Dietary Supplement: 50 g Xylitol; Dietary Supplement: 75 g Glucose; Dietary Supplement: 75 g Erythritol; Dietary Supplement: Tap water; Dietary Supplement: 1.56 g L-Leucine

Study type: Interventional

Funder types: Other

Identifiers

NCT02823249

fMRI Aminoacids

Details and patient eligibility

About

With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.

Enrollment: 20 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy normal weight subjects with a body-mass index of 19.0-24.9
• Healthy obese subjects with a body-mass index of > 30
• Normal eating habits (no diets; no dietary changes; no special dietary habits such as vegetarian/vegan)
• Age 18-40 years
• Stable body weight for at least three months

Exclusion criteria

• Smoking
• Substance abuse
• Regular intake of medications (except for oral contraceptives)
• Medical or psychiatric illness
• History of gastrointestinal disorders
• Food allergies
• Pregnancy, breast feeding
• Body piercings that cannot be removed
• History of claustrophobia
• Left-hander

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 6 patient groups, including a placebo group

1.56 g L-Tryptophan

Active Comparator group

Description:

1.56 g L-Tryptophan in 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube

Treatment:

Dietary Supplement: Tap water

Dietary Supplement: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

Device: Nasogastric Tube

Dietary Supplement: 1.56 g L-Tryptophan

1.56 g L-Leucine

Active Comparator group

Description:

1.56 g L-Leucine in 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube

Treatment:

Dietary Supplement: Tap water

Dietary Supplement: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

Device: Nasogastric Tube

Dietary Supplement: 1.56 g L-Leucine

50 g Xylitol

Active Comparator group

Description:

50 g Xylitol in 300 mL tap water given via nasogastric tube

Treatment:

Dietary Supplement: Tap water

Dietary Supplement: 50 g Xylitol

Device: Nasogastric Tube

75 g Erythritol

Active Comparator group

Description:

75 g Erythritol in 300 mL tap water given via nasogastric tube

Treatment:

Dietary Supplement: Tap water

Device: Nasogastric Tube

Dietary Supplement: 75 g Erythritol

75 g Glucose and mixed liquid meal

Placebo Comparator group

Description:

75 g Glucose in 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube

Treatment:

Dietary Supplement: Tap water

Dietary Supplement: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

Device: Nasogastric Tube

Dietary Supplement: 75 g Glucose

Tap water and mixed liquid meal

Placebo Comparator group

Description:

300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube

Treatment:

Dietary Supplement: Tap water

Dietary Supplement: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

Device: Nasogastric Tube