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Effect of Amlodipine on the Lipid Profile of Newly Diagnosed Hypertensive Patients

A

Ayub Teaching Hospital

Status and phase

Completed
Phase 4

Conditions

Cholesterol Deposition
Hypertension
Hypercholesterolemia

Treatments

Drug: Amlodipine

Study type

Interventional

Funder types

Other

Identifiers

NCT05467384
sashah0002

Details and patient eligibility

About

In this study, Amlodipine has been used to study its effects in newly diagnosed hypertensive patients.

Full description

The incidence of hypertension is on the rise in developing countries like Pakistan. Different medications are used to decrease blood pressure with Amlodipine as one of the first-line drugs. It was proposed that due to interaction with calcium and thus luminal cholecystokinin releasing factor; Amlodipine might increase the cholesterol level and thus cause dyslipidemia.

Objective: In this regard, this study was conducted to look into the effects of Amlodipine in newly diagnosed cases of hypertension that had received no medication previously.

Methodology: Experimental study with a healthy control group with the sample size calculated out to be 80, comprising of an equal number of enrolment into case and control groups.

Enrollment

80 patients

Sex

All

Ages

20 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for cases.

  1. Newly diagnosed mild to moderate hypertensive. (2) Non-obese individuals. 3) Must not have received antihypertensive treatment previously. 4) Has elevated serum cholesterol levels. Exclusion criteria for cases

  2. Any other major illness.

Inclusion criteria for controls

  1. Normal lipid profile.
  2. Normotensive (BP < 140/90mmHg). Exclusion criteria for controls
  1. Any major illness.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

80 participants in 2 patient groups

Newly Diagnosed Hypertensive patients
Experimental group
Description:
These are the patients that have been clearly diagnosed with diabetes for the first time.
Treatment:
Drug: Amlodipine
Healthy Controls
No Intervention group
Description:
Healthy Control Group

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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