Effect of Amlodipine on the Lipid Profile of Newly Diagnosed Hypertensive Patients

Ayub Teaching Hospital

Status and phase: Completed; Phase 4

Conditions: Cholesterol Deposition; Hypertension; Hypercholesterolemia

Treatments: Drug: Amlodipine

Study type: Interventional

Funder types: Other

Identifiers

NCT05467384

sashah0002

Details and patient eligibility

About

In this study, Amlodipine has been used to study its effects in newly diagnosed hypertensive patients.

Full description

The incidence of hypertension is on the rise in developing countries like Pakistan. Different medications are used to decrease blood pressure with Amlodipine as one of the first-line drugs. It was proposed that due to interaction with calcium and thus luminal cholecystokinin releasing factor; Amlodipine might increase the cholesterol level and thus cause dyslipidemia.

Objective: In this regard, this study was conducted to look into the effects of Amlodipine in newly diagnosed cases of hypertension that had received no medication previously.

Methodology: Experimental study with a healthy control group with the sample size calculated out to be 80, comprising of an equal number of enrolment into case and control groups.

Enrollment: 80 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for cases.

1. Newly diagnosed mild to moderate hypertensive. (2) Non-obese individuals. 3) Must not have received antihypertensive treatment previously. 4) Has elevated serum cholesterol levels. Exclusion criteria for cases

2. Any other major illness.

Inclusion criteria for controls

1. Normal lipid profile.
2. Normotensive (BP < 140/90mmHg). Exclusion criteria for controls

1. Any major illness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Newly Diagnosed Hypertensive patients

Experimental group

Description:

These are the patients that have been clearly diagnosed with diabetes for the first time.

Treatment:

Drug: Amlodipine

Healthy Controls

No Intervention group

Description:

Healthy Control Group