Effect of Amnion Membrane With and Without Taurine on GCF TNF α Level.

Maharishi Markendeswar University (Deemed to be University)

Status: Completed

Conditions: Periodontitis

Treatments: Procedure: Scaling and root planing; Biological: Amnion membrane; Drug: Taurine

Study type: Interventional

Funder types: Other

Identifiers

NCT04772508

13/395

Details and patient eligibility

About

45 sites in 15 patients with periodontal pockets ≥ 5mm were selected. These selected sites were divided into 3 groups as Group A, B and C.

Full description

Group A (Control): 15 sites received only SRP, Group B: 15 sites received SRP with subgingival placement of amnion membrane, Group C: 15 sites received SRP with subgingival placement of Amnion membrane hydrated with Taurine.

Enrollment: 45 patients

Sex: All

Ages: 29 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

•Systemically healthy patients with sites showing probing depth (PD) ≥ 5mm, clinical attachment level (CAL) ≥ 4 mm, and vertical bone loss ≥ 3 mm on intraoral periapical radiographs with no history of periodontal therapy or use of antibiotics in the preceding 6 months

Exclusion criteria

• Any systemic disease that could influence the outcome of periodontal therapy.
• Smokers, alcoholics & patients with other adverse habits.
• Pregnant or nursing women.
• Any known allergy or hypersensitivity to any product used in the study.
• Patients on long term systemic therapy (antibiotics, anti-inflammatory and any other).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

45 participants in 3 patient groups

Group A

Sham Comparator group

Description:

15 sites received only scaling and root planing

Treatment:

Procedure: Scaling and root planing

Group B

Active Comparator group

Description:

15 sites received scaling and root planing with subgingival placement of amnion membrane

Treatment:

Biological: Amnion membrane

Procedure: Scaling and root planing

Group C

Active Comparator group

Description:

15 sites received scaling and root planing with subgingival placement of amnion membrane hydrated with Taurine

Treatment:

Drug: Taurine

Biological: Amnion membrane

Procedure: Scaling and root planing