Effect of an Acute Bout of Exercise on Smoking Satisfaction

University of Western Ontario, Canada

Status: Completed

Conditions: Cancer

Treatments: Behavioral: Passive Sitting Group; Behavioral: Moderate Exercise Group

Study type: Interventional

Funder types: Other

Identifiers

NCT01417975

SmokingTopography1114

Details and patient eligibility

About

Female and male smokers will complete questionnaires and smoking behavior will be examined. After abstaining from smoking for approximately 18 hours, they will be randomized to a moderate intensity exercise groups or passive sitting group. Smoking satisfaction and smoking behavior will be assessed following treatment.

The hypotheses detailed below are specific to the randomization of participants into the following 2 groups:

1. Moderate exercise (Experimental condition; MEG)
2. Passive sitting (Attention control condition; PSG)

Hypothesis 1: A bout of moderate intensity exercise will be associated with decreased smoking satisfaction after a temporary period of abstinence compared to a control condition.

Hypothesis 2: Smoking topographic measures will mediate the relationship between a bout of moderate intensity exercise and smoking satisfaction.

Full description

Lung cancer is the leading cause of cancer death in Canadians (Canadian Cancer Society (CCS), 2010). Cigarette smoking is responsible for 85% of these cases (CCS, 2007). Exercise has been shown to be an effective adjunct to pharmacological cessation strategies (Ussher, Taylor, & Faulkner, 2008). A recent systematic review concluded that a single bout of low to moderate intensity exercise can help regulate cravings, withdrawal symptoms and negative affect associated with quitting (Taylor, Ussher, & Faulkner, 2007).

Smoking satisfaction is an immediately reinforcing effect of nicotine. Smoking satisfaction may outweigh the temporally distant adverse health risks of smoking (Cappelleri, Bushmakin, Baker, Merikle, Olufade, & Gilbert, 2007). Varenicline, an alpha 4-beta-2 nAChR partial agonist, mimics the effect of nicotine by reducing cravings and withdrawal symptoms (Coe et al., 2005). A 12-week treatment period of varenicline has been shown to reduce smoking satisfaction (Jorenby et al., 2006). However, the effect of acute exercise on smoking satisfaction is not yet known.

Smoking topography is a key facet of smoking behaviour. Smoking behaviour can be subjectively or objectively measured by quantifying puff volume, maximum puff velocity, inter-puff interval, puff duration, number of puffs per cigarette and time to smoke a single cigarette. Smoking topography can estimate exposure to carcinogenic toxins present in cigarette smoking (Djordjevic, Hoffman, & Hoffman, 1997). Evidence exists to support that exercise modifies smoking topography (Katomeri & Taylor 2006; Mikhail, 1983; Reeser, 1983; Zacny & Stitzer, 1985).

Enrollment: 43 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 64 years of age
• Smoke 10 or more cigarettes per day
• Not have any medical condition that is contraindicative for exercise
• Not be pregnant or intending on becoming pregnant over the course of the study
• Be able to read and write in English
• Have a telephone or e-mail account so they can be contacted
• Successful completion of the Physical Activity Readiness Questionnaire (PAR-Q)
• Have a Medical Doctor's clearance if they answer "YES" to one or more questions on the Physical Activity Readiness Questionnaire (PAR-Q)
• Have not been engaged in a serious quit attempt in the last six months
• Have been smoking for more than 2 years
• Must not be suffering from an illness (e.g. cold) that would affect their typical smoking behaviour

Exclusion criteria

• Contraindication to exercise (e.g. disability, unstable angina)
• On medication for physical and/or mental health reasons that would make compliance with the study protocol difficult or dangerous
• Have substance dependency problems (e.g. alcohol)
• Are pregnant
• Be younger than 18 years of age
• Be 64 years or older prior to completion of the study
• Have been engaged in a serious quite attempt in the last six months
• Have been smoking for less than 2 years
• Suffering from an illness (e.g. cold) that would affect their typical smoking behaviour

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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43 participants in 2 patient groups

Moderate Exercise Group

Experimental group

Description:

The moderate exercise condition will involve participants waking briskly (equivalent to moderate intensity) on a treadmill for 10 minutes. Moderate intensity exercise is defined as 40-68% of heart rate reserve (HRR). Heart rate (HR) will be monitored using a Polar RS100 Heart Rate monitor to serve as a guide for participants to attain the appropriate intensity.

Treatment:

Behavioral: Moderate Exercise Group

Passive Sitting Group

Active Comparator group

Description:

The passive sitting condition will involve participants sitting passively in a chair for 10 minutes. Heart rate (HR) will be monitored in participants of the passive sitting group to help maintain group equivalency (with the moderate exercise condition) with regards to distraction effects and researcher contact.

Treatment:

Behavioral: Passive Sitting Group