Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training

German Cancer Research Center

Status and phase: Completed; Phase 2

Conditions: Weight Loss; Hodgkin Disease; Bronchial Carcinoma; Gastrointestinal Neoplasms; Non-Hodgkin Lymphoma

Treatments: Drug: N-acetylcysteine

Study type: Interventional

Funder types: Other

Identifiers

NCT00196885

whilde157/2003

Details and patient eligibility

About

The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and function as well as histomorphology.

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• gastrointestinal or bronchial cancer
• weight loss of 10% within 6 months
• sufficient mobility

Exclusion criteria

• severe pain, steroid therapy, severe internal, muscular, neurological, psychiatric disease, N-acetylcysteine allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind