Effect of Anaesthesia on ER Stress in Cancer Patients

Konkuk University Medical Center

Status: Completed

Conditions: Endoplasmic Reticulum Stress

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT03561831

KUH1160108

Details and patient eligibility

About

Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Full description

We hypothesize propofol and sevoflurane based anesthesia would show different pattern of endoplasmic reticulum stress after cancer surgery in patients with cancer

Enrollment: 53 patients

Sex: Female

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with cancer

Exclusion criteria

• age under 19 years old
• allergy history to propofol or sevoflurane
• history of previous cancer

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Quadruple Blind

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53 participants in 2 patient groups

propofol group

Active Comparator group

Description:

patients who anesthesized by propofol

Treatment:

Drug: Propofol

sevoflurane group

Active Comparator group

Description:

patients who anesthesized by sevoflurane

Treatment:

Drug: Sevoflurane