Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

Yonsei University

Status: Completed

Conditions: Hip Fracture

Treatments: Drug: Bupivacaine; Drug: Propofol; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02458547

4-2015-0088

Details and patient eligibility

About

Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial. Due to old age, poor patient condition and emergent clinical settings, patients undergoing surgical procedures for hip fracture management are often subject to poor postoperative outcome and high mortality rates. While many studies have reported that regional anesthesia leads to improved postoperative outcome after hip fracture surgery, others have concluded otherwise. Moreover, because the majority of these previous studies are retrospective cohorts or systemic reviews, there is a need for randomized clinical trials to provide high quality evidence. This study aims to compare patient outcome between three different anesthetic techniques in elderly patients undergoing surgery for hip fracture management by evaluating proinflammatory cytokines, chemistry lab testing and clinical outcome between general anesthesia with either desflurane or propofol-based TIVA and spinal anesthesia with bupivacaine.

Enrollment: 186 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients older than 65 years scheduled for elective or emergency hip fracture surgery.

Exclusion criteria

1. Patient refusal
2. Inflammation or wound at puncture site, increased intracranial pressure, bleeding diathesis
3. Allergies to propofol or its ingredients, soybeans or peanuts
4. Patients with altered mental status
5. Illiterate patients or foreigners

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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186 participants in 3 patient groups

Group D

Experimental group

Description:

General anesthesia with desflurane

Treatment:

Drug: Desflurane

Group P

Active Comparator group

Description:

General anesthesia with propofol total intravenous anesthesia

Treatment:

Drug: Propofol

Group S

Active Comparator group

Description:

Spinal anesthesia with 0.5% bupivacaine

Treatment:

Drug: Bupivacaine