Effect of Anesthetic Agents on Optic Nerve Sheath Diameter

Hallym University Kangnam Sacred Heart Hospital

Status: Completed

Conditions: Uterine Cancer; Uterus Myoma

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT03701529

2018-09-004

Details and patient eligibility

About

The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.

Full description

Anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. Sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. On the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases.

Optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. Female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.

Enrollment: 42 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy

Exclusion criteria

• history of brain hemorrhage or brain infarction
• liver disease or end stage renal disease
• glaucoma or any signs of increased intraocular pressure
• combined wtih other types of operation
• patient refusal
• weight less than 40 kg or over 100 kg

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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42 participants in 2 patient groups

Sevoflurane

Experimental group

Description:

1.5-2.5 vol% of sevoflurane is used for maintenance of anesthesia.

Treatment:

Drug: Sevoflurane

Propofol

Active Comparator group

Description:

2-5 mcg/ml of propofol is used continuously for maintenance of anesthesia using target-controlled infusion system.

Treatment:

Drug: Propofol