Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP

Asan Medical Center

Status: Completed

Conditions: Prostate Cancer

Treatments: Drug: Dexmedetomidine; Other: Without dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03529643

20180523

Details and patient eligibility

About

The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.

Full description

The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Enrollment: 128 patients

Sex: Male

Ages: 20 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergone a robot-assisted laparoscopic prostatectomy with a prostate - cancer
• 20 years of age or older and under 80 years of age
• Agree to participate in this study

Exclusion criteria

• History of cerebral hemorrhage or cerebral infarction
• < 20 years of age
• ≥ 80 years of age
• Glaucoma
• Unexpected hemodynamic instability during surgery
• Failure to measure optic nerve sheath diameter
• Convert to open surgery

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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128 participants in 2 patient groups, including a placebo group

Anesthesia with dexmedetomidine

Experimental group

Description:

Anesthesia with sevoflurane-remifentanil-dexmedetomidine Dexmedetomidine :Continuous infusion of dexmedetomidine with loading dose of 1.0 μg/kg (0.25 ml/kg) for 10 minutes, then followed by maintenance dose of 0.4 µg/kg/hr (0.1 ml/kg/hr).

Treatment:

Drug: Dexmedetomidine

Anesthesia without dexmedetomidine

Placebo Comparator group

Description:

Anesthesia with sevoflurane-remifentanil Normal saline :Continuous infusion of normal saline with loading dose (0.25 ml/kg) for 10 minutes, then followed by maintenance dose (0.1 ml/kg/hr).

Treatment:

Other: Without dexmedetomidine