Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP

A

Asan Medical Center

Status

Completed

Conditions

Prostate Cancer

Treatments

Drug: Dexmedetomidine
Other: Without dexmedetomidine

Study type

Interventional

Funder types

Other

Identifiers

NCT03529643
20180523

Details and patient eligibility

About

The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.

Full description

The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Enrollment

128 patients

Sex

Male

Ages

20 to 79 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Undergone a robot-assisted laparoscopic prostatectomy with a prostate - cancer
  • 20 years of age or older and under 80 years of age
  • Agree to participate in this study

Exclusion criteria

  • History of cerebral hemorrhage or cerebral infarction
  • < 20 years of age
  • ≥ 80 years of age
  • Glaucoma
  • Unexpected hemodynamic instability during surgery
  • Failure to measure optic nerve sheath diameter
  • Convert to open surgery

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

128 participants in 2 patient groups, including a placebo group

Anesthesia with dexmedetomidine
Experimental group
Description:
Anesthesia with sevoflurane-remifentanil-dexmedetomidine Dexmedetomidine :Continuous infusion of dexmedetomidine with loading dose of 1.0 μg/kg (0.25 ml/kg) for 10 minutes, then followed by maintenance dose of 0.4 µg/kg/hr (0.1 ml/kg/hr).
Treatment:
Drug: Dexmedetomidine
Anesthesia without dexmedetomidine
Placebo Comparator group
Description:
Anesthesia with sevoflurane-remifentanil Normal saline :Continuous infusion of normal saline with loading dose (0.25 ml/kg) for 10 minutes, then followed by maintenance dose (0.1 ml/kg/hr).
Treatment:
Other: Without dexmedetomidine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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