Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation

Seoul National University

Status: Completed

Conditions: Mechanical Ventilation Complication

Treatments: Drug: propofol; Drug: desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02191371

PaO2 & StO2 in OLV

Details and patient eligibility

About

One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.

Full description

Patients undergoing thoracic surgery including one-lung ventilation will be randomized to receive intravenous (propofol) or inhalational (desflurane) anesthetic.

Systemic oxygenation can be evaluated by measuring partial pressure of oxygen in arterial blood analysis. Microcirculatory parameters can be obtained from vascular occlusion test. Among those parameters, recovery slope during vascular occlusion test is known to reflect recruitment of microvasculature in response to hypoxic or ischemic insult. In this study, we will compare arterial partial pressure of oxygen and recovery slope during one-lung ventilation between propofol and desflurane group.

Enrollment: 104 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing thoracic surgery including one-lung ventilation

Exclusion criteria

• refuse to enroll
• BMI over 30 kg/m(2)
• severe obstructive or restrictive lung disease
• preoperative supplemental oxygen, intubated, or mechanical ventilatory support
• preoperative arterial partial pressure of oxygen < 60 mmHg
• pregnancy
• history of coronary artery disease
• preoperative continuous infusion of vasopressor or inotropes
• cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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104 participants in 2 patient groups

propofol

Experimental group

Description:

Propofol is used as a maintenance anesthetic to patients in the propofol group. Intervention: propofol infusion by target-controlled infusion for maintaining anesthesia propofol (Fresofol MCT 2%) target effect site concentration: 4\~5 mcg/ml, during general anesthesia

Treatment:

Drug: propofol

desflurane

Experimental group

Description:

Desflurane is used as a maintenance anesthetic to patients in the desflurane group. Intervention: Desflurane administration for maintaining anesthesia desflurane (Suprane) inhalation as 6\~8 vol% during general anesthesia

Treatment:

Drug: desflurane