Effect of Anthocyanins Extracted From Purple Potatoes on Healthy Study Subjects' Postprandial Glycemia and Insulinemia

University of Turku

Status: Completed

Conditions: Postprandial Glycemia

Treatments: Other: Dietary

Study type: Interventional

Funder types: Other

Identifiers

NCT02940080

Siniset perunat 2

Details and patient eligibility

About

A randomized, single-blind cross-over clinical nutrition trial will be conducted. The effects of yellow-fleshed potatoes and yellow-fleshed potatoes supplemented with anthocyanins extracted from purple-fleshed potatoes on healthy men's postprandial glycemia and insulinemia will be compared. Additionally, the postprandial metabolism and metabolites, and the appearance and metabolism of the flavonoids and their metabolites is studied in plasma, urine and feces.

Enrollment: 18 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-45
• Male
• No regular medication
• No participation in a drug trial or blood donation within 2 months
• Non-smoker
• Signs informed consent
• Body mass index 18.5-27 kg/m2
• Fasting plasma cholesterol < 5.5 mmol/l
• Fasting plasma triacylglycerols < 2.6 mmol/l
• Fasting plasma glucose 4-6 mmol/l
• blood pressure <140/80 mmHg
• hemoglobin>130 g/l
• Fasting plasma alanine amino transferase (ALAT) <60 U/l (normal liver function)
• Fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
• Fasting plasma creatinine <118 µmol/l (normal kidney function)

Exclusion criteria

• Regular smoking
• Alcohol abuse
• Regular medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 2 patient groups

Anthocyanins and yellow potato

Experimental group

Description:

168 mg of anthocyanins extracted from purple-fleshed potatoes added to 350 g of steam-cooked mashed potatoes in water

Treatment:

Other: Dietary

Yellow potato

Experimental group

Description:

350 g of steam-cooked mashed potatoes in water

Treatment:

Other: Dietary