Effect of Anticoagulant Drug Intervention on Postoperative MALE and MACE in Patients With PAD

Zhejiang University

Status: Enrolling

Conditions: Antiplatelet Drug; Peripheral Arterial Disease; Anticoagulant Drugs

Treatments: Drug: anticoagulant or antiplatelet drugs

Study type: Observational

Funder types: Other

Identifiers

NCT05852197

IIT20230084B

Details and patient eligibility

About

Patients with PAD were grouped according to the combination of different anticoagulant and antiplate drugs. The type, dosage and duration of anticoagulant and antiplatelet drugs were recorded after operation. Major Adverse Cardiovascular Events and Major Adverse Limb Events were followed up at 1 month, 6 months and 12 months, respectively.

Enrollment: 6,000 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥50 years old
2. Patients with symptomatic PAD
3. Moderate intermittent claudication, or severe limb ischemia
4. Radiographically confirmed occlusion
5. Received a successful revascularization

Exclusion criteria

1. Acute limb ischemia occurred within 2 weeks before revascularization;
2. Large tissue defect of any lower limb (defined as obvious ulceration/gangrene near phalangeal head);
3. After revascularization, there are clinical conditions requiring systemic anticoagulation

Trial design

6,000 participants in 2 patient groups

Use a combination of anticoagulant or antiplatelet drugs ， group 1

Treatment:

Drug: anticoagulant or antiplatelet drugs

Use a combination of anticoagulant or antiplatelet drugs， group 2

Treatment:

Drug: anticoagulant or antiplatelet drugs