Effect of Antigens or Therapeutic Agents on in Vitro Human Intestinal Organoids

University of Erlangen-Nürnberg Medical School

Status: Active, not recruiting

Conditions: Intestine Disease

Study type: Observational

Funder types: Other

Identifiers

NCT03256266

intestinal organoids

Details and patient eligibility

About

The study evaluates the effect of nutrient antigens or therapeutic agents on human small intestinal organoids.

Full description

Small intestinal biopsies will be taken to establish human intestinal organoids in vitro. The organoids will be propagated and various antigens will be checked for their effects on proliferation, production of inflammatory components or signal cascade.

Enrollment: 375 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with gastrointestinal disorders and therapeutical indication of gastroduodenoscopy or coloscopy
• healthy controls for preventive medical check-up

Exclusion criteria

• pregnant women

Trial design

375 participants in 3 patient groups

healthy controls

Description:

healthy controls

patients with allergy

Description:

patients with Food intolerances or Food allergy

gastrointestinal disorders

Description:

patients with inflammatory bowel disease, irritable bowel disease, gluten sensitivity, short bowel syndrome