Effect of Antihypertensive Drugs on Glaucoma Patients

Zhejiang University

Status: Unknown

Conditions: Glaucoma

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04943107

2021-0287

Details and patient eligibility

About

It has been reported that among Asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness. In order to explore whether antihypertensive medications would influence the neuropathy among glaucomatous population, we designed a cross-sectional observational study to analyze the retinal status among glaucoma patients with use of antihypertensive medication.

Full description

we designed a cross-sectional obeservational study to analyze the retinal status among glaucoma patients with use of hyertensive medication.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age no less than 18 years

  • best corrected visual acuity better than decimal 0.3

Exclusion criteria

• secondary glaucoma

  • secondary hypertension
  • glaucoma-related operation history
  • pregnancy or lactation period
  • uncooperative with retinal examination
  • severe opacity with refracting media in eye
  • severe retinal diseases and neuropathy
  • congenital retinal optic nerve abnormality
  • other systemic diseases that influence hypertension and glaucoma assessment

Trial design

200 participants in 4 patient groups

healthy control

Description:

adults without glaucoma history or hypertension history

Treatment:

Other: no intervention

glaucoma patients

Description:

adults with primary glaucoma history; without glaucoma-related operation history; without hypertension history

Treatment:

Other: no intervention

hypertension patients

Description:

adults with primary hypertension history; without glaucoma history

Treatment:

Other: no intervention

glaucoma+hypertension

Description:

adults with primary glaucoma history and primary hypertension history; without glaucoma-related operation history

Treatment:

Other: no intervention