Effect of Antioxidant on Endurance Performance in Healthy Men

Seoul National University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Exercise Tolerance

Treatments: Dietary Supplement: Oligomerized litchi fruit extract; Other: placebo; Dietary Supplement: VItamin C + Vitamin E mixture

Study type: Interventional

Funder types: Other

Identifiers

NCT00731926

H-0707-028-212

Details and patient eligibility

About

oligomerized litchi fruit extract may enhance the submaximal endurance exercise performance

Full description

Regular physical exercise has many beneficial effects, but it has been reported that strenuous exercise could elevate the production of free radical and other reactive oxygen species (ROS) which eventually injure the tissues and decrease the muscle function.So many kinds of antioxidant supplementations have been tried to decrease the muscle fatigue and enhance the exercise performance. polyphenolic flavonoids abundant in fruits and leafy vegetables have strong antioxidant effect. oligomerized litchi fruit extract has strong antioxidant capacity and higher bioavailability compared to that of grape seed polyphenol. The aim of this study was to determine whether oligomerized litchi fruit extract could induce endurance exercise performance more than Vit C + Vit E mixture or placebo could do. Therefore, we designed double blind randomized controlled trial, setting the change of running time to exhaustion under submaximal treadmill test as the primary endpoint.

Enrollment: 69 patients

Sex: Male

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men over 20 years old non-smoker

Exclusion criteria

• BMI>25 or body fat>25% he who intakes the antioxidant supplement in recent 2 weeks

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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69 participants in 3 patient groups, including a placebo group

1

Experimental group

Treatment:

Dietary Supplement: Oligomerized litchi fruit extract

2

Active Comparator group

Treatment:

Dietary Supplement: VItamin C + Vitamin E mixture

3

Placebo Comparator group

Treatment:

Other: placebo