Effect of Antiviral Therapy on Host Immune in Patients With Chronic Hepatitis B Virus(HBV) Infection

Cz Li

Status: Completed

Conditions: HBeAg Positive Chronic Hepatitis B Infection

Treatments: Drug: Telbivudine

Study type: Interventional

Funder types: Other

Identifiers

NCT01480492

09zr400500 (Other Grant/Funding Number)

30972600 (Other Grant/Funding Number)

HBV20111115

Details and patient eligibility

About

During hepatitis B virus(HBV) infection host immune plays important role.Recently there are many different antiviral therapy methods.Different antiviral therapy methods showed different effector.In order to investigate whether these antiviral therapy methods especially methods directly inhibit viral replication have some effect on host immune the investigators designed these study. The investigators want to observe the change of host immune during antiviral therapy in patients with chronic HBV infection, and analyze the relationship between these changes and the antiviral effector of these drugs.

Enrollment: 56 patients

Sex: All

Ages: 18 to 66 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65 years old
• chronic HBV infection
• HBeAg positive,HBV DNA more than 10E5 IU/mL
• ALT ≥2×UTL

Exclusion criteria

• with liver cancer
• with liver failure
• pregnant

Trial design

56 participants in 1 patient group

therapy

No Intervention group

Treatment:

Drug: Telbivudine