Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

Suez Canal University

Status: Enrolling

Conditions: Postoperative Pain; Symptomatic Irreversible Pulpitis

Treatments: Procedure: Non-corticosteroid injection; Drug: Corticosteroid injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06457828

291/2020

Details and patient eligibility

About

The goal of this randomized clinical trial is to learn the effect of using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis in molar teeth. The main question it aims to answer is:

• How effective are using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis? Participants will be asked to fill a visual analogue scale to record their pain, after receiving a root canal treatment while using local corticosteroids or not as well as maintaining apical patency or not.

Researchers will compare the use of corticosteroids and maintaining apical patency in reducing post-operative pain.

Enrollment: 40 estimated patients

Sex: All

Ages: 21 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Symptomatic acute irreversible pulpitis in molar teeth.
• Normal periapical condition including periapical radiography with minimal widening of periodontal ligament.
• Normal probing depth.
• No medical condition.
• No contraindication for administration of corticosteroids and local anesthesia.

Exclusion criteria

• Facial or oral paresthesia.
• Pregnancy & breastfeeding.
• Unrestorable tooth.
• Marginal periodontal disease.
• Presence of a crown on the tooth involved.
• Over instrumentation during root canal treatment.
• Long-term use of corticosteroids.
• False-positive cases of sensibility test with necrosis discovered after gaining access to the tooth.
• Cases requiring intrapulpal injection to promote anesthesia.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups

No apical patency

Sham Comparator group

Treatment:

Drug: Corticosteroid injection

Procedure: Non-corticosteroid injection

Apical patency

Active Comparator group

Treatment:

Drug: Corticosteroid injection

Procedure: Non-corticosteroid injection