Effect of Apolipoprotein E on the Prognosis of Patients With Intracerebral Hemorrhage

The Affiliated Hospital Of Guizhou Medical University

Status: Completed

Conditions: Intracerebral Hemorrhage

Treatments: Diagnostic Test: Non-enhanced CT scan、Nuclear Magnetic Resonance (MRI)

Study type: Observational

Funder types: Other

Identifiers

NCT05687201

HL970570

Details and patient eligibility

About

The purpose of this observational study was to compare perihematomal edema and short-term prognosis in patients with intracerebral hemorrhage carrying the APOE-ε3 and APOE-ε4 genes. The main questions it aims to answer are:

• Exploring whether patients carrying the ApoE-ε4 gene have more perifocal perihematomal edema after intracerebral hemorrhage than patients with the ApoE-ε3 gene.
• ApoEε4 gene has worse short-term prognosis than ApoEε3 gene in intracerebral hemorrhage patients.

All the patients in this study received the same medications based on the guidelines for the management of hypertensive intracerebral hemorrhage.Some ICH patients were evaluated for Stereotactic minimally invasive surgery (sMIS) treatment by two experienced neurosurgeons.

Enrollment: 330 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Relevant diagnosis of supratentorial ICH was confirmed through unenhanced CT scanning.
• Patients were distinguished based on venous blood collection, with the presence of the ApoE-ε4 (ε2/ε4, ε3/ε4, ε4/ε4) gene (ApoE-ε4 genotype) and patients harboring the ApoE-ε3 (ε3/ε3) gene (non-ApoE-ε4 genotype).

Exclusion criteria

• Patients with infratentorial ICH.
• Patients with ApoE-ε2 (ε2/ε2) based on venous blood collections.
• Younger than 18 years of age.
• ICH caused by trauma, anticoagulation therapy, or antiplatelet therapy.
• Patients admitted to the hospital with diseases that might impact inflammatory responses, such as infective meningitis and systemic infections.
• Patients with previous residual neurological deficits following a stroke.
• Patients with combined tumours, severe liver and kidney dysfunction, cardiac insufficiency.

Trial design

330 participants in 2 patient groups

APOE-E4 (ε2/ε4,ε3/ε4,ε4/ε4) group

Description:

All the patients in this study received the same medications based on the guidelines for the management of hypertensive intracerebral hemorrhage.In addition, all patients received more comprehensive measures to prevent deep vein thrombosis (DVT), control blood pressure and glucose, nutritional support, and prevent other complications.

Treatment:

Diagnostic Test: Non-enhanced CT scan、Nuclear Magnetic Resonance (MRI)

APOEε3(ε3/ε3) group

Description:

All the patients in this study received the same medications based on the guidelines for the management of hypertensive intracerebral hemorrhage.In addition, all patients received more comprehensive measures to prevent deep vein thrombosis (DVT), control blood pressure and glucose, nutritional support, and prevent other complications.

Treatment:

Diagnostic Test: Non-enhanced CT scan、Nuclear Magnetic Resonance (MRI)