Effect of Apple Cider Vinegar and Metformin Combination vs Metformin Alone in Type 2 Diabetics

Ziauddin University

Status: Completed

Conditions: Diabetes Mellitus, Type 2

Treatments: Drug: Metformin Oral Tablet; Dietary Supplement: Vinegar

Study type: Interventional

Funder types: Other

Identifiers

NCT04120259

002

Details and patient eligibility

About

'This study aims to compare the effect of Metformin alone vs Metformin plus Apple Cider Vinegar in newly diagnosed Type 2 Diabetic Patients

Full description

Diabetes Mellitus is one of the oldest diseases known to men and has been treated with multiple agents,organic and with the current pharmacological advancement,with multiple synthetic drugs as well.

Metformin has been considered first line for the treatment of Type 2 Diabetes, however presents itself with a side effect profile of GI distress, Vitamin B12 deficiency,to name a few.

Vinegar has been used as therapeutic agent for centuries for multiple ailments including diabetes. This study aims to evaluate the combined effects of drug and natural therapy and compare it with conventional therapy.

Enrollment: 126 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Recently diagnosed Type 2 diabetic patients taking metformin 750 mg daily as the oral antidiabetic agent
• Patients with Hemoglobin A1c in the range of 6.5 to 7.5%

Exclusion criteria

• All newly diagnosed Diabetic Patients requiring a dosage other than 750 mg per day
• Patients on Insulin Therapy or any drugs for diabetes other than Metformin
• Pregnant and Lactating women
• Patients with food allergies to either apple or any source of vinegar
• Patients unable to communicate efficiently\mentally challenged
• Type 2 Diabetic patients with any of the complications of long standing uncontrolled diabetes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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126 participants in 2 patient groups

Group 1

Active Comparator group

Description:

Intervention: Metformin Tablet oral 750 mg OD

Treatment:

Drug: Metformin Oral Tablet

Group 2

Experimental group

Description:

Intervention: Metformin 750 mg oral plus 2 tablespoons of apple cider vinegar OD

Treatment:

Dietary Supplement: Vinegar

Drug: Metformin Oral Tablet