Effect of Aquatic Exercise and Traditional Physical Therapy on Gout in Hypertensive Menopausal Women With Hyperuricemia

Merit University

Status: Not yet enrolling

Conditions: Gout

Treatments: Other: the Aquatic exercises +Traditional physical therapy programs +anti-hyperuricemia medication; Other: traditional physical therapy + anti-hyperuricemia medication

Study type: Interventional

Funder types: Other

Identifiers

NCT05454423

A Eon gout

Details and patient eligibility

About

Aquatic Exercise and traditional physical therapy are effective methods of treatment for gout and hypertension in menopausal women.

Full description

Menopause is defined as a point in time 12 months after a woman's last period. During the menopausal transition, changes in estrogen and progesterone levels affect not only vasomotor symptoms, sexual dysfunction, osteoporosis, and cardiovascular disease (CVD), but also uric acid level1. An association between menopausal status and hyperuricemia has been previously examined. A study using the Third National Health and Nutrition Examination Survey showed a positive and independent association of menopause with hyperuricemia and gout. It's believed that estrogen has a protective effect that is removed at menopause, thus accounting for the rise in gout in women who are postmenopausal2.

Hyperuricemia is a common biochemical abnormality resulting from excessive uric acid production or impaired clearance of uric acid. Although its pathophysiology is not fully understood, genetic, comorbid disease-related, and environmental (drug, diet, and toxic exposure-induced) factors are involved in hyperuricemia3.

Gout is a multifactorial disease caused by hyperuricemia and monosodium urate crystals deposition. Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours. The joint at the base of the big toe is affected in about half of cases4.

Enrollment: 100 estimated patients

Sex: Female

Ages: 45 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 100 patients with gout

  • Age between 45 -65 years
  • Cooperative patient.
  • A physician referred all patients with the diagnosis of gout

Exclusion criteria

• history of kidney disease such as chronic kidney disease, Cancer patients. Smokers Patients with chronic heart disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups, including a placebo group

aquatic exercise + Traditional physical therapy + anti-hyperuricemia medication

Experimental group

Description:

consisted of 50 Patients received aquatic exercise and Traditional physical therapy in addition to anti-hyperuricemia medication (a potent purine xanthine oxidase (XO) inhibitor) in therapeutic dose.

Treatment:

Other: the Aquatic exercises +Traditional physical therapy programs +anti-hyperuricemia medication

traditional physical therapy + anti-hyperuricemia medication

Placebo Comparator group

Description:

consisted of 50 Patients received traditional physical therapy in addition to anti-hyperuricemia medication (a potent purine xanthine oxidase (XO) inhibitor) in therapeutic dose.

Treatment:

Other: traditional physical therapy + anti-hyperuricemia medication