Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Cairo University (CU)

Status: Not yet enrolling

Conditions: Post Operative Pain

Treatments: Drug: Ascorbic acid; Other: saline

Study type: Interventional

Funder types: Other

Identifiers

NCT05478044

ENDO 3 - 7 - 1

Details and patient eligibility

About

The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients above 18 years old and to 60.
• Male or female.
• Patients seeking root canal treatment.
• mandibular molar teeth with symptomatic irreversible pulpits with preoperative acute or moderate pain with hot and cold stimulation with normal periapical radiographic appearance .
• healthy patient (ASA I,II).
• Patient who can understand NRS and sign informed consent.

Exclusion criteria

• Medically compromised patients having significant systemic disorders. (ASA III or IV).
• History of intolerance to NSAIDS.
• External root resorption.
• Internal root resorption.
• Vertical root fracture.
• Periapical lesion.
• Pregnancy.
• Use of ibuprofen in the last 12 hour.
• Bleeding disorder.
• Long term corticosteroid use.
• Mobility Grade II or III.
• Pocket depth more than 5mm.
• Previous root canal therapy.
• Non-restorability.
• TMJ problems, bruxism, clenching or traumatic occlusion.
• Inability to perceive the given instructions.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups, including a placebo group

Ascorbic acid

Experimental group

Description:

Ascorbic acid IV ampoules 20% as a final flush irrigation 3ml after cleaning and shaping.

Treatment:

Drug: Ascorbic acid

Saline

Placebo Comparator group

Description:

A mixture of sodium chloride and water (0.9%) as a final flush irrigation 3 ml after cleaning and shaping.

Treatment:

Other: saline