Effect of ASEA on Energy Expenditure and Fat Oxidation in Humans

University of North Carolina (UNC)

Status: Completed

Conditions: Obesity

Treatments: Dietary Supplement: ASEA water; Dietary Supplement: Salt Water

Study type: Interventional

Funder types: Other

Identifiers

NCT01884727

12-1675

Details and patient eligibility

About

To test the effect of ASEA consumption on 24-hour resting energy expenditure. Hypothesis: consumption of 8-oz of ASEA water (4-oz before breakfast and 4-oz before bedtime) will significantly elevate 24-h resting energy expenditure as compared to consumption of a placebo control (salt water, same dietary intake).

Full description

The ASEA beverage is a special oral formulation produced from a pure saline solution containing 123 mg sodium and 129 mg chloride per 4 oz. serving. A proprietary electrolytic and catalytic process rearranges the salt water solution to mimic the redox signaling molecular composition of the native salt-water compounds found in and around human cells. Data obtained thus far, suggests the possibility that consumption of the ASEA beverage may increase energy expenditure and thus be beneficial for the treatment of obesity, however, this has not been assessed in human clinical studies. To this end, we will measure the effects of ASEA consumption on energy expenditure by indirect calorimetry using the indirect room calorimeter at the University of North Carolina (UNC) Nutrition Research Institute.

The primary outcome measures will be the change in 24-h energy expenditure and respiratory quotient in response to ASEA consumption. The secondary outcome variables will include changes in relevant peptide hormones, and norepinephrine/epinephrine and their relationship to changes in energy expenditure in response to consumption of ASEA.

Enrollment: 15 patients

Sex: Female

Ages: 50 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• woman
• postmenopausal
• healthy
• age 50-65
• BMI 25-35 kg/m²
• exercise less than 150 minutes per week
• weight neutral for past 6 months

Exclusion criteria

• smoker
• exercises more than 150 minutes per week
• abuses drugs or alcohol
• vegetarian
• taking herbal supplements, attention deficit hyperactivity disorder (ADHD) medication or thyroid medication
• taking beta-blockers, steroidal anti-inflammatory medication
• taking pseudoephedrine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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15 participants in 2 patient groups, including a placebo group

ASEA water

Active Comparator group

Description:

Subjects to consume 4-ounces of ASEA water at 9:00 am before breakfast and 4-ounces of ASEA water at 10:15 pm prior to bedtime. 24-h resting energy expenditure and RQ to be measured.

Treatment:

Dietary Supplement: ASEA water

Salt water

Placebo Comparator group

Description:

Subjects to consume 4-ounces of salt water at 9:00 am before breakfast and 4-ounces of salt water at 10:15 pm prior to bedtime. 24-h resting energy expenditure and RQ to be measured.

Treatment:

Dietary Supplement: Salt Water