Effect of Aspirin at the Acute Phase of Cerebral Ischemic Event.

Central Hospital, Nancy, France

Status: Unknown

Conditions: Ischemic Stroke

Treatments: Biological: blood sample; Drug: Aspirin

Study type: Interventional

Funder types: Other

Identifiers

NCT01375400

Aspirin

Details and patient eligibility

About

Aspirin is the only anti-platelet medication used at the acute phase of ischemic stroke. The investigators would like to study laboratory effect of the first oral 300 mg dose of aspirin, given at hospital, after an ischemic event.

The principal hypothesis is that platelet activity would be able to recover during this day and could lead to ischemic recurrences.

Two blood samples are accomplished. The first 2 hours after aspirin intake and the second 23 hours after. Photometric aggregometry are performed with arachidonic acid and collagen induced platelet aggregation, measure of thromboxan B2 levels and reticular platelets count.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult men and women
• Ischemic stroke less than 48 hours
• Signed consent

Exclusion criteria

• Danger to prescription of aspirin (haemorrhagic risk...)
• Prescription of heparin or VKA

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)