Effect of Astaxanthin Supplementation on Plasma Malondialdehyde Levels and NIHSS of Stroke Patients

University of Indonesia (UI)

Status and phase: Completed; Phase 1

Conditions: Malondialdehyde; Oxidative Stress; Cerebral Stroke

Treatments: Drug: Astaxanthine; Drug: Placebo Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT03945526

Neuronutrition

Details and patient eligibility

About

This is an interventional randomized, controlled trial in analyzing the effects of astaxanthin supplementation on plasma malondialdehyde levels and NIHSS of acute ischemic stroke patients. According to published studies, it was hypothesized that acute ischemic stroke patients who were given astaxanthin would have lower plasma malondialdehyde levels and lower NIHSS score compared to the control group.

Full description

There were a total of 24 subjects, with 12 subjects in the intervention group and 12 subjects in the control group.The participants were divided into an interventional group and a control group. The interventional group was given astaxanthin supplementation 2 x 8mg per day for 7 days, while the control group was given placebo.

Enrollment: 24 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 40-65 years old
• Has acute ischemic stroke with an onset of less than 48 hours before hospital admission
• NIHSS score of less than or equal to 15
• Can consume food orally or enterally
• Has given their consent to be a participant in the study

Exclusion criteria

• Renal failure
• Liver failure
• Is taking supplements other than his or her main stroke medications
• Has taken antioxidant supplements in the last 3 months before stroke onset

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups, including a placebo group

Astaxanthin

Active Comparator group

Description:

Astaxanthin supplementation will be given at 2 x 8mg for 7 days.

Treatment:

Drug: Astaxanthine

Control

Placebo Comparator group

Description:

A placebo will be given, which takes the form of a drug with the exact same shape and color as astaxanthin supplementation

Treatment:

Drug: Placebo Oral Tablet