Effect of AXOS on the Colon Metabolism in Healthy Volunteers

Catholic University (KU) of Leuven

Status and phase: Completed; Phase 2

Conditions: Gut Health

Treatments: Dietary Supplement: Arabinoxylanoligosaccharides; Dietary Supplement: Maltodextrine

Study type: Interventional

Funder types: Other

Identifiers

NCT01656499

ML7245

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of AXOS on parameters of colon metabolism and gut health

Enrollment: 20 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers
• regular dietary pattern (3 meals/day)
• age: 18-45y
• BMI: 18,5-27 kg/m2

Exclusion criteria

• intake of antibiotics 1 month prior to the study
• abdominal surgery in the past, with the exception of appendectomy
• intake of medication influencing the gastro-intestinal system 14 days prior to the study
• in treatment at a dietician
• serious liver- or kidney failure
• vegetarians
• intake of pre- and/or probiotics
• Exposure to radioactivity 1 year prior to the study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups, including a placebo group

Arabinoxylanoligosaccharides (AXOS)

Active Comparator group

Description:

AXOS (2 x 5g WBE/day)

Treatment:

Dietary Supplement: Arabinoxylanoligosaccharides

Maltodextrine (placebo)

Placebo Comparator group

Description:

Maltodextrine (2 x 5g/day)

Treatment:

Dietary Supplement: Maltodextrine