Effect of β-alanine Supplementation on Muscle Carnosine (LitmusMagnet)

Nestlé

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: beta-alanine; Dietary Supplement: placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00813553

08.13.PER

Details and patient eligibility

About

Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.

Full description

Volunteers will be randomized to receiving 3 nutritional supplements. Two supplements contain beta-alanine at different doses, the third supplement is a placebo.

Enrollment: 30 estimated patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Stable health as evaluated by medical evaluation
• Body mass index higher than 18 kg/m2
• Body mass index lower than 25 kg/m2, unless body fat is less than 20%

Exclusion criteria

• intolerance to β-alanine,
• allergy to soy, fish and crustacean
• participation in another intervention study
• consumer of dietary supplement susceptible to contain beta-alanine
• determined to have very high baseline muscle carnosine concentration

Trial design

30 participants in 3 patient groups, including a placebo group

beta-alanine 0

Placebo Comparator group

Treatment:

Dietary Supplement: placebo

beta-alanine 1

Experimental group

Treatment:

Dietary Supplement: beta-alanine

Dietary Supplement: beta-alanine

beta-alanine 2

Experimental group

Treatment:

Dietary Supplement: beta-alanine

Dietary Supplement: beta-alanine